|
Acute Erythroblastic Leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The use of this method permits the sensitive identification of GYPA transcripts in these cells and confirms GPA protein expression in the erythroleukemia cell lines and the MN phenotypes of individuals determined by immunolabeling with GPA allele-specific monoclonal antibodies.
|
7762218 |
1995 |
|
Adult Erythroleukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The use of this method permits the sensitive identification of GYPA transcripts in these cells and confirms GPA protein expression in the erythroleukemia cell lines and the MN phenotypes of individuals determined by immunolabeling with GPA allele-specific monoclonal antibodies.
|
7762218 |
1995 |
|
Erythroleukemia (Erythroid/Myeloid)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The use of this method permits the sensitive identification of GYPA transcripts in these cells and confirms GPA protein expression in the erythroleukemia cell lines and the MN phenotypes of individuals determined by immunolabeling with GPA allele-specific monoclonal antibodies.
|
7762218 |
1995 |
|
Bloom Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The flow cytometric patterns of erythrocytes from the BS patients showed a typical smear of variants bearing intermediate levels of expression of one GPA allele, indicating that the real variant frequency is even greater than that measured.
|
2677702 |
1989 |
|
Anemia, Sickle Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Greater than 50% of CD34<sup>+</sup> HSPCs from SCD BM are CD34<sup>dim</sup> due to higher erythroid lineage expression (P < 0·01) as single cell CD34<sup>+</sup> CD45<sup>+</sup> GPA<sup>+</sup> (P < 0·01) and CD34<sup>+</sup> CD45<sup>-</sup> GPA<sup>+</sup> (P < 0·01) HSPCs.
|
30972754 |
2019 |
|
Intracranial Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HLA antigens, blood group systems (ABO, Rh, MNSs, P, Kell, Lewis and Duffy) and serum group systems (Hp, Tf, Gc, Pi, Bf, C3 and C4) were studied in a series of patients with intracranial aneurysms.
|
3498681 |
1987 |
|
NEUROTICISM
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the individual level, GPA was a protective factor against negative affect, as it drove longitudinal decreases in Neuroticism.
|
31483860 |
2019 |
|
X-linked sideroblastic anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In two patients with X-linked sideroblastic anemia the levels of mRNA for erythroid ALAS as well as for alpha and beta globin appear to be decreased while levels of mRNA for glycophorin A in both patients were the same as in normal individuals.
|
1415186 |
1992 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
These findings suggest an essential role of the MSP1-GPA-band 3 complex during the initial adhesion phase of malaria parasite invasion of RBCs.
|
25778531 |
2015 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
Erythrocyte binding antigens 175 (EBA-175) and 140 (EBA-140) play key roles in erythrocyte invasion by binding to glycophorin A (GPA) and C (GPC) respectively in human malaria.
|
29128519 |
2018 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
GPA is the receptor for the binding ligand EBA-175 of the malaria parasite, Plasmodium falciparum.
|
12949139 |
2003 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
These results are consistent with malaria acting as a selective pressure on GYPA, but also suggest that another selective force has resulted in a similar pattern of variation in Europeans.
|
29362874 |
2018 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
The conjugation of antibodies against glycophorin A targeted the nanocarriers to <i>Plasmodium</i>-infected red blood cells and to gametocytes, the sole malaria parasite stage responsible for the transmission from the human to the mosquito vector.
|
31315185 |
2019 |
|
Skin Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Total GPA variant frequency in arsenic-exposed patients bearing skin tumors was significantly increased compared to patients without skin tumors (167 versus 290).
|
17029826 |
2006 |
|
Malignant neoplasm of skin
|
0.300 |
Biomarker
|
disease |
CTD_human |
Increased glycophorin A somatic cell variant frequency in arsenic-exposed patients of Guizhou, China.
|
17029826 |
2006 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
EBA-175 is a Plasmodium falciparum micronemal protein that binds to sialic acid in the context of the peptide backbone of glycophorin A and has been implicated in sialic acid-dependent invasion of erythrocytes.
|
10989151 |
2000 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest an essential role of the MSP1-GPA-band 3 complex during the initial adhesion phase of malaria parasite invasion of RBCs.
|
25778531 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The molecular mechanism(s) responsible for these host restrictions are not understood, although the interaction between the parasite blood-stage invasion ligand EBA175 and the host erythrocyte receptor Glycophorin-A (GYPA) has been implicated previously.
|
24297912 |
2013 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
EBA-175 mediates sialic acid-dependent binding to glycophorin A on the erythrocytes playing a crucial role during invasion of the P. falciparum in the host cell.
|
21615944 |
2011 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results support the hypothesis that African P. falciparum parasites use GYPA as a primary receptor for invasion.
|
12654801 |
2003 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In contrast, erythrocyte invasion via the EBA-175/glycophorin A route appears to have been disrupted to such a degree that the mutant lines have undergone a stable switch in invasion phenotype.
|
10861015 |
2000 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Erythrocyte Binding Antigen of 175 kDa (EBA-175) has a well-defined role in binding to glycophorin A (GpA) during <i>Plasmodium falciparum</i> invasion of erythrocytes.
|
30556808 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Erythrocyte binding antigens 175 (EBA-175) and 140 (EBA-140) play key roles in erythrocyte invasion by binding to glycophorin A (GPA) and C (GPC) respectively in human malaria.
|
29128519 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A 175 kDa Plasmodium falciparum erythrocyte binding antigen (EBA-175) binds sialic acid residues on glycophorin A during invasion of human erythrocytes.
|
12165386 |
2002 |